Clinical trials articles

Jan 11, 2021 · Clinical trials are a form of medical research that follow a defined protocol that has been carefully developed to answer a specific patient care question. Clinical trials are in use to test cancer therapies, treatments for cardiovascular disease, the safety and efficacy of new drugs, and a number of other conditions. The newly published New Drugs and Clinical Trials Rules, 2019 will be referred as New Rules, 2019 in this article. The new rules are structured around 13 chapters (including 107 rules) and eight schedules. The new rules will apply to all new drugs, investigational new drugs for human use, clinical trials, bioequivalence and bioavailability ...The New England journal of medicine 357 (14), 1365-1368 (2007). Wadman, M., The quiet rise of the clinical contractor. Nature 441 (7089), 22-23 (2006). Baigent, C., Harrell, F.E., Buyse, M., Emberson, J.R., & Altman, D.G., Ensuring trial validity by data quality assurance and diversification of monitoring methods.People volunteer to take part in clinical trials to test medical interventions including drugs, cells and other biological products, surgical procedures, radiological procedures, devices, behavioural treatments and preventive care. Clinical trials are carefully designed, reviewed and completed, and need to be approved before they can start.The evolution of clinical research traverses a long and fascinating journey. The recorded history of clinical trials goes back to the biblical descriptions in 500 BC. The journey moves from dietary therapy – legumes and lemons – to drugs. After basic approach of clinical trial was described in 18th century, the efforts were made to refine ... To be in a trial for a new EGFR-positive NSCLC treatment, you may need to: Be at least 18 years old. Have confirmed NSCLC of a certain stage. Have an EGFR mutation. Be reasonably healthy otherwise ...Jan 28, 2022 · Articles Treatment begins with knowledge. Article 1 Oral and Intravenous Hydration in the treatment of Orthostatic Hypotension and Postural Tachycardia Syndrome Autonomic Neuroscience: Basic & Clinical … Clinical Research Articles Read More » A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. ClinicalTrials.gov includes both interventional and observational studies. Focusing on phase 3 trials, the Pharmaceutical Research and Manufacturers of America estimated the cost at $42,000 per patient in 2013, with $10 billion spent on 1680 phase 3 clinical trials comprising over 600,000 patients. Certain studies present unique cost considerations. alliance valor toy hauler Clinical trials are an essential tool in medical research, but COVID-19 has exposed ways that their design, conduct, and reporting could be improved. The rapid design and launch of clinical trials designed to research COVID-19 has shown that certain aspects and practices of clinical trials could be improved, streamlined, or modernised in ways ...Jan 28, 2022 · Articles Treatment begins with knowledge. Article 1 Oral and Intravenous Hydration in the treatment of Orthostatic Hypotension and Postural Tachycardia Syndrome Autonomic Neuroscience: Basic & Clinical … Clinical Research Articles Read More » Clinical Trials Day is celebrated around the world in May to recognize the day that James Lind started what is often considered the first randomized clinical trial aboard a ship on May 20, 1747. Here's the story* May, 1747.This article focusses exclusively on those clinical trials that are conducted to prove the safety and efficacy of the therapeutic product being tested. Preparing to conduct a clinical trial While preparing to conduct a clinical trial, it is useful to review the main elements noted above in order to ensure that the framework that will govern the ...Each clinical trial also follows a careful study plan or protocol that describes what the researchers will do. The principal investigator, or head researcher, is responsible for making sure that the protocol is followed. An Institutional Review Board, or IRB, at each study site must approve every clinical trial in the United States. The IRB is ... Over 5000 peer-reviewed articles on clinical research, trials, nurse CPD, nursing ideas, and all other aspects of nursing. Login / Register Menu Menu . Sign In; ... Keep up to date with clinical articles, news and opinion in your clinical subject or nursing role/setting or browse our range of teaching and CPD resources.Ethical Guidelines. The goal of clinical research is to develop generalizable knowledge that improves human health or increases understanding of human biology. People who participate in clinical research make it possible to secure that knowledge. The path to finding out if a new drug or treatment is safe or effective, for example, is to test it ...Clinical trials are studies intended to discover or verify the effects of one or more investigational medicines.. The regulation of clinical trials aims to ensure that the rights, safety and well-being of trial participants are protected and the results of clinical trials are credible.. Regardless of where they are conducted, all clinical trials included in applications for marketing ...A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. ClinicalTrials.gov includes both interventional and observational studies. Clinical Trials in Preterm Infants. A 2012 systematic review on timing of umbilical cord clamping in preterm infants analyzed the results from 15 eligible studies that involved 738 infants born between 24 weeks and 36 weeks of gestation 4.This review defined delayed umbilical cord clamping as a delay of more than 30 seconds, with a maximum of 180 seconds, and included some studies that also ...The conduct of clinical trials in the EU under existing legislation suffers from disharmonized interpre- tation and wide variation in execution across member states. This has led to excessive administrative and regulatory burden, costs and delays—and ultimately a significant drop in the number of trials conducted in the region.We developed an easy-to-implement frailty index, the Clinical Trial-Frailty Index (CT-FI), based on baseline medical history and standard patient-reported outcomes using data from clinical trials of recombinant Zoster vaccine (the ZOE-50 and ZOE-70 studies). Our objective was to demonstrate that the CT-FI is a robust measure that may be used ...NCCIH Clinical Trials. Find clinical trials that are recruiting patients (ClinicalTrials.gov) Join a Study - Clinical and Scientific Assessment of Pain and Painful Disorders. Completed Trials (ClinicalTrials.gov)The Colombia trial was just the latest in a series of trials of crenezumab and other antiamyloid therapies that have failed to show a clinical benefit. A recent review article in the Journal of Alzheimer Disease identified 9 compounds targeting amyloid that had failed in phase 3 trials since 2018.A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. ClinicalTrials.gov includes both interventional and observational studies. Clinical Trials / Drug Trials What to know about aducanumab — the new medication for dementia Aducanumab is a new medication for treating early dementia, or mild Alzheimer's disease. Diversity & Inclusion in Clinical Trials. Our health is a combination of physical and mental well-being, which is affected by our behavior, biology, environment, societal policies, and importantly, our lived experiences. The lived experiences of people in the U.S. vary based on their race and ethnicity, socioeconomic status (SES), geographic ...Each clinical trial also follows a careful study plan or protocol that describes what the researchers will do. The principal investigator, or head researcher, is responsible for making sure that the protocol is followed. An Institutional Review Board, or IRB, at each study site must approve every clinical trial in the United States. The IRB is ... A single clinical trial can result in multiple publications: the study protocol and traditional results paper or papers, as well as commentaries, secondary analyses and, eventually, systematic reviews, among others, many published in different journals, years apart. This situation is further complicated by an ever-growing body of literature.In recent years, patients, researchers and research funding organizations have increasingly recognized that patients should be actively involved in the design, conduct and dissemination of clinical research [1,2,3,4].Normative and substantive rationales [5, 6] argue for "research being carried out 'with' or 'by' members of the public rather than 'to', 'about' or 'for ... animal shelter inventory Studies and patients. The integrated clinical trial safety dataset included data pooled from 21 randomized controlled clinical trials of secukinumab in PsO (14 Phase 3 trials and 1 Phase 4 trial; N = 5181), PsA (3 Phase 3 trials; N = 1380), and AS (3 Phase 3 trials; N = 794) indications (see Fig. 1 for details), along with post-marketing surveillance data for secukinumab across the PsO, PsA ...Clinical trials are one of the final stages of a long and careful research process. The process often begins in a laboratory (lab), where scientists first develop and test new ideas. If an approach seems promising, the next step may involve animal testing. This shows how the approach affects a living body and whether it's harmful.The FDA issued draft guidance 3 on enhancing the diversity of clinical trial populations in the summer of 2019 and finalized the guidance in November 2020. 4. The Multi-Regional Clinical Trials (MRCT) Center of Brigham and Women's Hospital and Harvard formed an MRCT Center Diversity Workgroup in February 2018 and published a guidance document ...clinical trial is a research study that tests a new medical treatment or a new way of using an existing treatment to see if it will be a better way to prevent and screen for diagnose or treat a disease1.For any new drug to enter in clinical trial, it must pass preclinical studies. Preclinical studies involve in...FDA Issues Draft Guidance on Diversity and Inclusion in Clinical Trials. Wednesday, August 10, 2022. With its disproportionately greater impact on minority populations in the United States, the ...Research Topics At the foundation of Johns Hopkins Medicine is research - from basic research, where scientists study cells and mechanisms, to clinical research that builds on those findings using trials, to translational research that takes information learned from trials to the patient bedside. Browse Research Topics Latest NewsApr 04, 2022 · Figure 1. Practical approaches, by study phase, for inclusion of women in clinical research. For each study phase, a model checklist of actionable steps for the inclusion of women, and underrepresented subgroups of women, is presented. The study phases are divided into three parts: pre-study, on-study, and follow-up. tg comics The numbers of participants ranged from twenty four in the smallest [] to seventy four in the largest study [].Five trials were included in the meta-analysis [33,34,35,36,37] and five were eligible but the data presentation did not allow them to be included in the meta-analysis [23, 38,39,40,41].Of the ten studies, five trials included patients with formally diagnosed anxiety disorders [23, 34 ...Jan 28, 2022 · Articles Treatment begins with knowledge. Article 1 Oral and Intravenous Hydration in the treatment of Orthostatic Hypotension and Postural Tachycardia Syndrome Autonomic Neuroscience: Basic & Clinical … Clinical Research Articles Read More » A clinical trial is a research study done in people that helps health care providers understand the best approach to prevent, diagnose, treat, or manage symptoms of diseases, including cancer. Clinical trials can be used to evaluate a wide range of biomedical (e.g., treatment) and behavioral (e.g., exercise and diet) interventions. Clinical trials are studies intended to discover or verify the effects of one or more investigational medicines.. The regulation of clinical trials aims to ensure that the rights, safety and well-being of trial participants are protected and the results of clinical trials are credible.. Regardless of where they are conducted, all clinical trials included in applications for marketing ...The SOFA score—development, utility and challenges of accurate assessment in clinical trials Simon Lambden, Pierre Francois Laterre, Mitchell M. Levy & Bruno Francois Critical Care 23, Article number: 374 ( 2019 ) Cite this article 47k Accesses 202 Citations 69 Altmetric Metrics AbstractThis need is a large driving force behind drug discovery's mission to uncover new medicines. The drug discovery process is complex and stubborn. The clinical stage, in particular, is resource intensive, demanding and high risk. A fine balance is required to execute this stage correctly. Clinical Research Organisations (CROs) supporting drug ...High quality laboratory results derived from the analysis of samples collected from clinical trial participants are a key part of the clinical trial process. They provide critical data that is used for evidence-based decision making about an investigational medicinal product's safety, efficacy and mechanism of action, and to improve standard ...A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. ClinicalTrials.gov includes both interventional and observational studies. Clinical Therapeutics provides peer-reviewed, rapid publication of recent developments in drug and other therapies as well as in diagnostics, pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research. In addition Clinical Therapeutics features updates on specific topics collated by expert Topic Editors. planet 7 casino no deposit bonus codes 2022 existing players Clinical Trials. Clinical trials are the research studies that involves people & to know how new medical approaches work in people. Every clinical trial has a protocol, or action plan, for conducting the trial. Clinical trials provide scientific ways to treat or prevent diseases. Clinical trials may be conducted by the agencies such as NIH ...clinical trial is a research study that tests a new medical treatment or a new way of using an existing treatment to see if it will be a better way to prevent and screen for diagnose or treat a disease1.For any new drug to enter in clinical trial, it must pass preclinical studies. Preclinical studies involve in...A collection of articles that examine the current challenges in the design, performance, and interpretation of clinical trials. Latest Articles on Clinical Trials, Review Article The Changing Face...Explore 427,488 research studies in all 50 states and in 221 countries. See listed clinical studies related to the coronavirus disease (COVID-19) ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine. IMPORTANT: Listing a study does not mean it has been evaluated by the U.S. Federal Government. Phases of drug development. Phase I clinical trials: Researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects. Phase II clinical trials: The study drug or treatment is given to a larger group of people (100-300) to see if it is ...Clinical Nutrition Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice.International Journal of Clinical Trials (IJCT) complies with the uniform requirements for manuscripts submitted to biomedical journals, issued by the International Committee for Medical Journal Editors. Issues: 4 per year Email: [email protected] , [email protected] Print ISSN: 2349-3240 Online ISSN: 2349-3259CLINICAL TRIAL (CT): Clinical trials are clinical research studies involving human participants assigned to an intervention in which the study is designed to evaluate the effect(s) of the intervention on the participant and the effect being evaluated is a health-related biomedical or behavioral outcome.Clinical trials are medical studies that involve people like you. They help find new ways to prevent, detect, or treat diseases that are safe and effective. The National Heart, Lung, and Blood Institute (NHLBI) leads and supports many studies aimed at preventing, diagnosing, and treating heart, lung, blood, and sleep disorders.Clinical trials 1. Dr. Sirisha 1st year PG CLINICAL TRIALS 2. DEFINITION • It is a prospective ethically designed investigation in human subjects to discover/verify/compare the results of two or more therapeutic measures /drugs. michigan state fraternities rankingiot weather station raspberry piLast modified on Fri 21 Jan 2022 00.28 EST. The billionaire entrepreneur Elon Musk's brain chip startup is preparing to launch clinical trials in humans. Musk, who co-founded Neuralink in 2016 ...After entering a search term and clicking Search, scroll down the Filters list, located on the left side of the page. Click the + sign next to Study Results, and select With Results. Then click Apply (located at the bottom and top of the Filters list). Click on the study title to display the study record or the words Has Results to go directly ... ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world. Explore 406,391 research studies in all 50 states and in 220 countries. See listed clinical studies related to the coronavirus disease (COVID-19) ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine.Clinical trials: Drug development Drug development is often complex, time-consuming and resource-intensive. It requires particular attention to ensure the appropriateness of the clinical trial being conducted for the drug or biologic. Adequate and well-controlled clinical studies2 days ago · By collecting and analyzing data in real-time, artificial intelligence can assist a company in monitoring a clinical trial. These AI solutions can gather a large amount of data from various sources, allowing doctors or researchers to understand better how patients react during a drug trial. Clinical research provides a wealth of operational ... Clinical Trial News. This section provides information about recently completed clinical trials. If you cannot find information about a particular clinical trial, you should note that results may not be available even after the trial ends. Some trials end before completion and results are never published. Clinical trials primarily enroll white, male patients, with consistent underrepresentation of women, the elderly, and people of color — especially Black and Hispanic patients. While people of ...clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study …For this article, we use the example of a new medication treatment going through the clinical trial process. What happens in phase 0? Phase 0 of a clinical trial is done with a very small number ...Jan 24, 2018 · Clinical Trials. January 24, 2018 Clinical trials and you. When you volunteer to take part in clinical research, you help doctors and researchers learn more about ... clinical trial is a research study that tests a new medical treatment or a new way of using an existing treatment to see if it will be a better way to prevent and screen for diagnose or treat a disease1.For any new drug to enter in clinical trial, it must pass preclinical studies. Preclinical studies involve in... 5 tips in buying a mobile phone ISSN: 1179-1519. An international, peer- reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of clinical trial design, management, legal, ethical and regulatory issues, case record form design, data collection, quality assurance and data auditing methodologies.Apr 09, 2020 · These studies may help identify new possibilities for clinical trials. Clinical trials are research studies performed in people that are aimed at evaluating a medical, surgical, or behavioral intervention. They are the primary way that researchers find out if a new treatment, like a new drug or diet or medical device (for example, a pacemaker ... A vaccine for Lyme disease is in its final clinical trial. August 9, 202212:25 PM ET. Bill Chappell. Twitter. Enlarge this image. A vaccine candidate for Lyme disease is moving through the ...endpoint of a clinical trial. Pivotal clinical trial data from the 3 marketed COVID-19 vaccines was reanalyzed using "all cause severe morbidity", a scientific measure of health, as the primary endpoint. "All cause severe morbidity" in the treatment group and control group was calculated by adding all severe events reported in the ...Editor-in-Chief. Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine ...Behavioral clinical trials focus on interventions that aim to increase positive behaviors such as physical activity or cancer screenings, eliminate negative behaviors such as smoking, and/or improve quality of life for those with illness. Observational studies are not considered clinical trials.There are several criteria for which clinical trials are eligible for coverage of their routine costs. Trials that are deemed to be automatically qualified include: trials funded by NIH, CDC, AHRQ, CMS, DOD, and VA; trials supported by centers or cooperative groups that are funded by NIH, CDC, AHRQ, CMS, DOD, and VA; traktor araba Clinical Trials. Clinical trials are procedures followed in development of new drugs. Clinical trials can also be behavioral studies which are formulated to find treatments for specific behavioral symptoms. Clinical trials procedures can be comparative in some cases. Related Journals of Clinical Trials Behavioral clinical trials focus on interventions that aim to increase positive behaviors such as physical activity or cancer screenings, eliminate negative behaviors such as smoking, and/or improve quality of life for those with illness. Observational studies are not considered clinical trials.Clinical trials testing new treatments are divided into different stages, called phases. The earliest phase trials may look at whether a drug is safe or the side effects it causes. Later phase trials aim to test whether a new treatment is better than existing treatments. There are 3 main phases of clinical trials - phases 1 to 3.The COVID-19 pandemic has clearly changed the world and the consequences on the conduct of clinical trials are manifold, including, but not limited to: Concerns about the safety of patients as well...The past year has also brought results from clinical trials using CRISPR technology, which we first reported on in 2019, and the start of new clinical trials. In this new review article, we will ...Explore 427,488 research studies in all 50 states and in 221 countries. See listed clinical studies related to the coronavirus disease (COVID-19) ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine. IMPORTANT: Listing a study does not mean it has been evaluated by the U.S. Federal Government. Each clinical trial also follows a careful study plan or protocol that describes what the researchers will do. The principal investigator, or head researcher, is responsible for making sure that the protocol is followed. An Institutional Review Board, or IRB, at each study site must approve every clinical trial in the United States. The IRB is ... Apr 09, 2020 · These studies may help identify new possibilities for clinical trials. Clinical trials are research studies performed in people that are aimed at evaluating a medical, surgical, or behavioral intervention. They are the primary way that researchers find out if a new treatment, like a new drug or diet or medical device (for example, a pacemaker ... clinical trial is a research study that tests a new medical treatment or a new way of using an existing treatment to see if it will be a better way to prevent and screen for diagnose or treat a disease1.For any new drug to enter in clinical trial, it must pass preclinical studies. Preclinical studies involve in...Appropriate uses of clinical trials . A clinical trial is a ppropriate to evaluate which is the most cost effective drug choice. Clinical trials are also appropriate for evaluating whether a new device achieves a certain goal as effectively and safely as standard devices. However, investigating the causes of Parkinson's disease, for example, is ... The past year has also brought results from clinical trials using CRISPR technology, which we first reported on in 2019, and the start of new clinical trials. In this article, we will go over the basics of clinical trials and then map out the current CRISPR-based trials from disease background to what we really hope to learn from these trials.2 days ago · By collecting and analyzing data in real-time, artificial intelligence can assist a company in monitoring a clinical trial. These AI solutions can gather a large amount of data from various sources, allowing doctors or researchers to understand better how patients react during a drug trial. Clinical research provides a wealth of operational ... Build Relationships with HCPs to Reach Potential Clinical Trial Patients September 13, 2022 Increased outreach is necessary to combat poor recruitment and large focus on patients near study centers. Trialbee Introduces Trialbee Honey™ Analytics September 13, 2022 Real-time monitoring module now available in SaaS-based platform. how to fix buzzing noise in headphonesClinical Trials Database is providing to the public a listing of specific information relating to phase I, II and III clinical trials in patients. It provides a source of information about clinical trials involving human pharmaceutical and biological drugs. Jan 11, 2021 · Clinical trials are a form of medical research that follow a defined protocol that has been carefully developed to answer a specific patient care question. Clinical trials are in use to test cancer therapies, treatments for cardiovascular disease, the safety and efficacy of new drugs, and a number of other conditions. Behavioral clinical trials focus on interventions that aim to increase positive behaviors such as physical activity or cancer screenings, eliminate negative behaviors such as smoking, and/or improve quality of life for those with illness. Observational studies are not considered clinical trials.Clinical trials with any intervention using stem cells/cells derived from dental tissue were included. A total of 815 studies were identified by the electronic search, and 38 articles qualified for full-text evaluation. Finally, 20 studies (10 clinical trials using dental pulp-derived cells, 3 clinical trials using periodontal ligament-derived ...Recent Articles, Defining demographic cohorts in clinical trial populations using large electronic health records databases, Stephen J. Peroutka October 30, 2022, Study design for a proactive teachable moment tobacco treatment intervention among patients with pulmonary nodules, Stephanie Unger, Sara E. Golden and 6 more October 30, 2022,Clinical Trial News. This section provides information about recently completed clinical trials. If you cannot find information about a particular clinical trial, you should note that results may not be available even after the trial ends. Some trials end before completion and results are never published. costco bathroom vanity 48 inchAn AMIA Clinical Research Informatics group could be well poised to identify the gaps and devise strategies to fill them. They would also be able to address relationships between clinical research data collection standards and EHR specifications, as well as the broad issue of secondary use of clinical data for research.Jan 28, 2022 · Articles Treatment begins with knowledge. Article 1 Oral and Intravenous Hydration in the treatment of Orthostatic Hypotension and Postural Tachycardia Syndrome Autonomic Neuroscience: Basic & Clinical … Clinical Research Articles Read More » A preclinical study demonstrated that combining docetaxel with pan-NOS inhibitor NG-monomethyl- l -arginine acetate (L-NMMA) in a xenograft model of MDA-MB-231 decreased Ki67 proliferating cells, enhanced tumor apoptosis, and reduced tumor-initiating capacity of residual tumor cells after chemotherapy to a larger degree than docetaxel alone [ 29 ].Between 54.0 and 93.8% of the trials did not plan to include older people or those with a higher baseline risk. Most studies were randomised (67.9%), single-centre (58.3%), non-industry-funded (81.1%), to be conducted in China (47.6%), with a median duration of 184 days and a median sample size of 100 participants.People volunteer to take part in clinical trials to test medical interventions including drugs, cells and other biological products, surgical procedures, radiological procedures, devices, behavioural treatments and preventive care. Clinical trials are carefully designed, reviewed and completed, and need to be approved before they can start.Clinical trial disclosure is an evolving topic, with almost daily published contributions worldwide. The initial goal some 20 years ago of requirements that clinical trials be registered in a publicly accessible database was to inform patients, relatives, and treating physicians that a clinical trial exists, thereby making the enrolmentClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world. Explore 406,391 research studies in all 50 states and in 220 countries. See listed clinical studies related to the coronavirus disease (COVID-19) ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine.Regeneron Pharmaceuticals stock was on pace for its largest percentage increase since 2011 on Thursday after the pharmaceutical company announced promising results from late-stage clinical trials ... jason and piper fanfiction high school xa